diff --git a/.ci/build-mac.sh b/.ci/build-mac.sh
index ae0341cc0e..5b39b1ad2a 100755
--- a/.ci/build-mac.sh
+++ b/.ci/build-mac.sh
@@ -9,23 +9,12 @@ AVVER="${COMM_TAG}-${COMM_COUNT}"
 export LVER="${COMM_TAG}-${COMM_COUNT}-${COMM_HASH}"
 echo "AVVER=$AVVER" >> .ci/ci-vars.env
 
-export HOMEBREW_NO_AUTO_UPDATE=1
-export HOMEBREW_NO_INSTALLED_DEPENDENTS_CHECK=1
-export HOMEBREW_NO_ENV_HINTS=1
-export HOMEBREW_NO_INSTALL_CLEANUP=1
-brew install -f --overwrite --quiet ccache "llvm@$LLVM_COMPILER_VER"
-brew link -f --overwrite --quiet "llvm@$LLVM_COMPILER_VER"
-brew install -f --overwrite --quiet googletest opencv@4 sdl3 vulkan-headers vulkan-loader molten-vk
-brew unlink --quiet ffmpeg fmt qtbase qtsvg qtdeclarative protobuf || true
+# Clang depends on LLVM_COMPILER_VER so it needs to be installed here.
+sudo port install "clang-$LLVM_COMPILER_VER"
 
 export CXX=clang++
 export CC=clang
 
-export BREW_PATH;
-BREW_PATH="$(brew --prefix)"
-export BREW_BIN="$BREW_PATH/bin"
-export BREW_SBIN="$BREW_PATH/sbin"
-
 export WORKDIR;
 WORKDIR="$(pwd)"
 
@@ -53,20 +42,16 @@ cd "$WORKDIR"
 ditto "/tmp/Qt/$QT_VER" "qt-downloader/$QT_VER"
 
 export Qt6_DIR="$WORKDIR/qt-downloader/$QT_VER/clang_64/lib/cmake/Qt$QT_VER_MAIN"
-export SDL3_DIR="$BREW_PATH/opt/sdl3/lib/cmake/SDL3"
+export SDL3_DIR="/opt/local/lib/cmake/SDL3"
+export OpenCV_DIR="/opt/local/libexec/opencv4"
+export PATH="/opt/local/libexec/llvm-$LLVM_COMPILER_VER/bin:/$WORKDIR/qt-downloader/$QT_VER/clang_64/bin:/opt/local/bin:/opt/local/sbin:/usr/bin:/bin:/usr/sbin:/sbin:/opt/X11/bin:/Library/Apple/usr/bin:$PATH"
+export LDFLAGS="-L/opt/local/lib -Wl,-rpath,/opt/local/lib"
+export VULKAN_SDK="/opt/local"
+export LLVM_DIR="/opt/local/libexec/llvm-$LLVM_COMPILER_VER"
 
-export PATH="$BREW_PATH/opt/llvm@$LLVM_COMPILER_VER/bin:$PATH"
-export LDFLAGS="-L$BREW_PATH/opt/llvm@$LLVM_COMPILER_VER/lib/c++ -L$BREW_PATH/opt/llvm@$LLVM_COMPILER_VER/lib/unwind -lunwind"
-
-export VULKAN_SDK
-VULKAN_SDK="$BREW_PATH/opt/molten-vk"
-ln -s "$BREW_PATH/opt/vulkan-loader/lib/libvulkan.dylib" "$VULKAN_SDK/lib/libvulkan.dylib"
-
-export LLVM_DIR
-LLVM_DIR="$BREW_PATH/opt/llvm@$LLVM_COMPILER_VER"
 # Pull all the submodules except some
 # shellcheck disable=SC2046
-git submodule -q update --init --depth=1 --jobs=8 $(awk '/path/ && !/llvm/ && !/opencv/ && !/SDL/ && !/feralinteractive/ { print $3 }' .gitmodules)
+git submodule -q update --init --depth=1 --jobs=8 $(awk '/path/ && !/llvm/ && !/opencv/ && !/libsdl-org/ && !/feralinteractive/ && !/curl/ && !/zlib/ { print $3 }' .gitmodules)
 
 mkdir build && cd build || exit 1
 # The below should be uncommented once bugs with Qt 6 QListWidgets when using the OS 26 visual style are resolved.
@@ -91,7 +76,7 @@ cmake .. \
     -DUSE_SYSTEM_OPENCV=ON \
     -G Ninja
 
-ninja -j4; build_status=$?;
+ninja; build_status=$?;
 
 cd ..
 
diff --git a/.ci/deploy-mac.sh b/.ci/deploy-mac.sh
index 4125e2379b..a2b3cc810f 100755
--- a/.ci/deploy-mac.sh
+++ b/.ci/deploy-mac.sh
@@ -5,15 +5,12 @@ cd build || exit 1
 
 cd bin
 mkdir -p "rpcs3.app/Contents/Resources/vulkan/icd.d" || true
-wget https://github.com/KhronosGroup/MoltenVK/releases/download/v1.4.2-rc1/MoltenVK-macos-privateapi.tar
+wget https://github.com/KhronosGroup/MoltenVK/releases/download/v1.4.2/MoltenVK-macos-privateapi.tar
 tar -xvf MoltenVK-macos-privateapi.tar
 cp "MoltenVK/MoltenVK/dynamic/dylib/macOS/libMoltenVK.dylib" "rpcs3.app/Contents/Frameworks/libMoltenVK.dylib"
 cp "MoltenVK/MoltenVK/dynamic/dylib/macOS/MoltenVK_icd.json" "rpcs3.app/Contents/Resources/vulkan/icd.d/MoltenVK_icd.json"
 sed -i '' "s/.\//..\/..\/..\/Frameworks\//g" "rpcs3.app/Contents/Resources/vulkan/icd.d/MoltenVK_icd.json"
 
-cp "$(realpath $BREW_PATH/opt/llvm@$LLVM_COMPILER_VER/lib/c++/libc++abi.1.0.dylib)" "rpcs3.app/Contents/Frameworks/libc++abi.1.dylib"
-cp "$(realpath $BREW_PATH/opt/gcc/lib/gcc/current/libgcc_s.1.1.dylib)" "rpcs3.app/Contents/Frameworks/libgcc_s.1.1.dylib"
-
 rm -rf "rpcs3.app/Contents/Frameworks/QtPdf.framework" \
 "rpcs3.app/Contents/Frameworks/QtQml.framework" \
 "rpcs3.app/Contents/Frameworks/QtQmlModels.framework" \
@@ -52,26 +49,6 @@ rm -f rpcs3.app/Contents/translations/qt_help_*.qm || true
 mv rpcs3.app RPCS3_.app
 mv RPCS3_.app RPCS3.app
 
-# Hack to fix rpath issues
-BIN="RPCS3.app/Contents/MacOS/rpcs3"
-install_name_tool -delete_rpath /opt/homebrew/lib $BIN || true
-install_name_tool -delete_rpath /usr/local/lib $BIN || true
-
-# Fix dylib IDs
-for lib in RPCS3.app/Contents/Frameworks/*.dylib; do
-  name=$(basename "$lib")
-  install_name_tool -id "@rpath/$name" "$lib"
-done
-
-# Rewrite any hardcoded Homebrew paths to use @rpath
-find "RPCS3.app/Contents/" -type f \( -perm +111 -o -name "*.dylib" \) | while read -r bin; do
-  otool -L "$bin" | grep -E "/opt/homebrew|/usr/local" | awk '{print $1}' | while read -r dep; do
-    base=$(basename "$dep")
-    echo "Fixing $dep -> @rpath/$base in $bin"
-    install_name_tool -change "$dep" "@rpath/$base" "$bin"
-  done
-done
-
 # NOTE: "--deep" is deprecated
 codesign --deep -fs - RPCS3.app
 
diff --git a/.github/parameters/setup-macports.yaml b/.github/parameters/setup-macports.yaml
new file mode 100644
index 0000000000..1da4c67d44
--- /dev/null
+++ b/.github/parameters/setup-macports.yaml
@@ -0,0 +1,9 @@
+ports:
+  - name: abseil
+  - name: ccache
+  - name: gtest
+  - name: opencv4
+  - name: sdl3
+  - name: vulkan-headers
+  - name: vulkan-loader
+  - name: MoltenVK
diff --git a/.github/workflows/rpcs3.yml b/.github/workflows/rpcs3.yml
index 68e1356bc8..ece64449a8 100644
--- a/.github/workflows/rpcs3.yml
+++ b/.github/workflows/rpcs3.yml
@@ -185,12 +185,17 @@ jobs:
       RELEASE_MESSAGE: ../GitHubReleaseMessage.txt
       UPLOAD_COMMIT_HASH: ${{ matrix.UPLOAD_COMMIT_HASH }}
       UPLOAD_REPO_FULL_NAME: ${{ matrix.UPLOAD_REPO_FULL_NAME }}
-      RUN_UNIT_TESTS: ${{ matrix.name == 'Apple Silicon' && (github.event_name == 'pull_request' && 'ON') || 'OFF' }}
+      RUN_UNIT_TESTS: github.event_name == 'pull_request' && 'ON' || 'OFF'
     steps:
       - name: Checkout repository
         uses: actions/checkout@main
         with:
           fetch-depth: 0
+          
+      - name: Setup MacPorts
+        uses: melusina-org/setup-macports@v1
+        with:
+            cache: 'disable'
 
       - name: Restore Build Ccache
         uses: actions/cache/restore@main
diff --git a/rpcs3/Emu/RSX/GL/OpenGL.h b/rpcs3/Emu/RSX/GL/OpenGL.h
index 2ecf773d79..9ee25840c5 100644
--- a/rpcs3/Emu/RSX/GL/OpenGL.h
+++ b/rpcs3/Emu/RSX/GL/OpenGL.h
@@ -16,11 +16,6 @@ typedef BOOL (WINAPI* PFNWGLSWAPINTERVALEXTPROC) (int interval);
 #undef OPENGL_PROC
 #undef WGL_PROC
 #undef OPENGL_PROC2
-
-#elif defined(__APPLE__)
-#include <OpenGL/gl.h>
-#include <OpenGL/glu.h>
-
 #else
 #include <GL/gl.h>
 #ifdef HAVE_X11
diff --git a/rpcs3/rpcs3qt/gui_application.cpp b/rpcs3/rpcs3qt/gui_application.cpp
index 5ab02365b6..9b5105e47d 100644
--- a/rpcs3/rpcs3qt/gui_application.cpp
+++ b/rpcs3/rpcs3qt/gui_application.cpp
@@ -56,7 +56,10 @@
 #include <clocale>
 
 #include "Emu/RSX/Null/NullGSRender.h"
+
+#ifndef __APPLE__
 #include "Emu/RSX/GL/GLGSRender.h"
+#endif
 
 #if defined(HAVE_VULKAN)
 #include "Emu/RSX/VK/VKGSRender.h"