diff --git a/Common/GPU/Vulkan/VulkanLoader.cpp b/Common/GPU/Vulkan/VulkanLoader.cpp
index 6cab42ef55..ca404021f8 100644
--- a/Common/GPU/Vulkan/VulkanLoader.cpp
+++ b/Common/GPU/Vulkan/VulkanLoader.cpp
@@ -294,6 +294,10 @@ static VulkanLibraryHandle VulkanLoadLibrary(std::string *errorString) {
 	return nullptr;
 #elif PPSSPP_PLATFORM(UWP)
 	return nullptr;
+#elif PPSSPP_PLATFORM(MACOS) && PPSSPP_ARCH(AMD64)
+	// Disable Vulkan on Mac/x86. Too many configurations that don't work with MoltenVK
+	// for whatever reason.
+	return nullptr;
 #elif PPSSPP_PLATFORM(WINDOWS)
 	return LoadLibrary(L"vulkan-1.dll");
 #else