diff --git a/Core/Config.cpp b/Core/Config.cpp
index e4adbd12ff..9ddda1a9e9 100644
--- a/Core/Config.cpp
+++ b/Core/Config.cpp
@@ -406,7 +406,6 @@ static bool DefaultSasThread() {
 
 static ConfigSetting cpuSettings[] = {
 	ReportedConfigSetting("CPUCore", &g_Config.iCpuCore, &DefaultCpuCore, true, true),
-	ReportedConfigSetting("SeparateCPUThread", &g_Config.bSeparateCPUThread, false, true, true),
 	ReportedConfigSetting("SeparateSASThread", &g_Config.bSeparateSASThread, &DefaultSasThread, true, true),
 	ReportedConfigSetting("SeparateIOThread", &g_Config.bSeparateIOThread, true, true, true),
 	ReportedConfigSetting("IOTimingMethod", &g_Config.iIOTimingMethod, IOTIMING_FAST, true, true),
diff --git a/Core/Config.h b/Core/Config.h
index 37dd1373fe..6a1d4c2134 100644
--- a/Core/Config.h
+++ b/Core/Config.h
@@ -132,8 +132,6 @@ public:
 	bool bFuncReplacements;
 	bool bHideSlowWarnings;
 
-	// Definitely cannot be changed while game is running.
-	bool bSeparateCPUThread;
 	bool bSeparateSASThread;
 	bool bSeparateIOThread;
 	int iIOTimingMethod;
diff --git a/Core/System.cpp b/Core/System.cpp
index 04c93deeb1..6f7069f1f2 100644
--- a/Core/System.cpp
+++ b/Core/System.cpp
@@ -392,10 +392,10 @@ void System_Wake() {
 // Ugly!
 static bool pspIsInited = false;
 static bool pspIsIniting = false;
-static bool pspIsQuiting = false;
+static bool pspIsQuitting = false;
 
 bool PSP_InitStart(const CoreParameter &coreParam, std::string *error_string) {
-	if (pspIsIniting || pspIsQuiting) {
+	if (pspIsIniting || pspIsQuitting) {
 		return false;
 	}
 
@@ -415,7 +415,9 @@ bool PSP_InitStart(const CoreParameter &coreParam, std::string *error_string) {
 	coreParameter.errorString = "";
 	pspIsIniting = true;
 
-	if (g_Config.bSeparateCPUThread) {
+	// Keeping this around because we might need it in the future.
+	const bool separateCPUThread = false;
+	if (separateCPUThread) {
 		Core_ListenShutdown(System_Wake);
 		CPU_SetState(CPU_THREAD_PENDING);
 		cpuThread = new std::thread(&CPU_RunLoop);
@@ -438,7 +440,7 @@ bool PSP_InitUpdate(std::string *error_string) {
 		return true;
 	}
 
-	if (g_Config.bSeparateCPUThread && !CPU_IsReady()) {
+	if (!CPU_IsReady()) {
 		return false;
 	}
 
@@ -459,7 +461,8 @@ bool PSP_InitUpdate(std::string *error_string) {
 bool PSP_Init(const CoreParameter &coreParam, std::string *error_string) {
 	PSP_InitStart(coreParam, error_string);
 
-	if (g_Config.bSeparateCPUThread) {
+	// For a potential resurrection of separate CPU thread later.
+	if (false) {
 		CPU_WaitStatus(cpuThreadReplyCond, &CPU_IsReady);
 	}
 
@@ -472,12 +475,12 @@ bool PSP_IsIniting() {
 }
 
 bool PSP_IsInited() {
-	return pspIsInited && !pspIsQuiting;
+	return pspIsInited && !pspIsQuitting;
 }
 
 void PSP_Shutdown() {
 	// Do nothing if we never inited.
-	if (!pspIsInited && !pspIsIniting && !pspIsQuiting) {
+	if (!pspIsInited && !pspIsIniting && !pspIsQuitting) {
 		return;
 	}
 
@@ -488,7 +491,7 @@ void PSP_Shutdown() {
 #endif
 
 	// Make sure things know right away that PSP memory, etc. is going away.
-	pspIsQuiting = true;
+	pspIsQuitting = true;
 	if (coreState == CORE_RUNNING)
 		Core_UpdateState(CORE_ERROR);
 	Core_NotifyShutdown();
@@ -507,7 +510,7 @@ void PSP_Shutdown() {
 	currentMIPS = 0;
 	pspIsInited = false;
 	pspIsIniting = false;
-	pspIsQuiting = false;
+	pspIsQuitting = false;
 	g_Config.unloadGameConfig();
 }
 
@@ -532,8 +535,9 @@ void PSP_RunLoopUntil(u64 globalticks) {
 		return;
 	}
 
-	// Switch the CPU thread on or off, as the case may be.
-	bool useCPUThread = g_Config.bSeparateCPUThread;
+	// We no longer allow a separate CPU thread but if we add a render queue
+	// to GL we're gonna need it.
+	bool useCPUThread = false;
 	if (useCPUThread && cpuThread == nullptr) {
 		// Need to start the cpu thread.
 		Core_ListenShutdown(System_Wake);
diff --git a/GPU/GPUCommon.cpp b/GPU/GPUCommon.cpp
index 53b39e6d32..84873b5133 100644
--- a/GPU/GPUCommon.cpp
+++ b/GPU/GPUCommon.cpp
@@ -359,11 +359,11 @@ GPUCommon::GPUCommon(GraphicsContext *gfxCtx, Draw::DrawContext *draw) :
 	// The compiler was not rounding the struct size up to an 8 byte boundary, which
 	// you'd expect due to the int64 field, but the Linux ABI apparently does not require that.
 	static_assert(sizeof(DisplayList) == 456, "Bad DisplayList size");
-	listLock.set_enabled(g_Config.bSeparateCPUThread);
+	listLock.set_enabled(false);
 
 	Reinitialize();
 	SetupColorConv();
-	SetThreadEnabled(g_Config.bSeparateCPUThread);
+	SetThreadEnabled(false);
 	gstate.Reset();
 	gstate_c.Reset();
 	gpuStats.Reset();
diff --git a/GPU/Software/SoftGpu.cpp b/GPU/Software/SoftGpu.cpp
index 812c164cb2..89b8383fb0 100644
--- a/GPU/Software/SoftGpu.cpp
+++ b/GPU/Software/SoftGpu.cpp
@@ -913,11 +913,6 @@ bool SoftGPU::PerformStencilUpload(u32 dest, int size)
 }
 
 bool SoftGPU::FramebufferDirty() {
-	if (g_Config.bSeparateCPUThread) {
-		// Allow it to process fully before deciding if it's dirty.
-		SyncThread();
-	}
-
 	if (g_Config.iFrameSkip != 0) {
 		bool dirty = framebufferDirty_;
 		framebufferDirty_ = false;
diff --git a/UI/GameSettingsScreen.cpp b/UI/GameSettingsScreen.cpp
index 5baed5463e..7579c65aaa 100644
--- a/UI/GameSettingsScreen.cpp
+++ b/UI/GameSettingsScreen.cpp
@@ -661,13 +661,6 @@ void GameSettingsScreen::CreateViews() {
 
 	systemSettings->Add(new CheckBox(&g_Config.bFastMemory, sy->T("Fast Memory", "Fast Memory (Unstable)")))->OnClick.Handle(this, &GameSettingsScreen::OnJitAffectingSetting);
 
-	auto separateCPUThread = new CheckBox(&g_Config.bSeparateCPUThread, sy->T("Multithreaded (experimental)"));
-	systemSettings->Add(separateCPUThread);
-	separateCPUThread->OnClick.Add([=](EventParams &e) {
-		if (g_Config.bSeparateCPUThread)
-			settingInfo_->Show(sy->T("Multithreaded Tip", "Not always faster, causes glitches/crashing"), e.v);
-		return UI::EVENT_CONTINUE;
-	});
 	systemSettings->Add(new CheckBox(&g_Config.bSeparateIOThread, sy->T("I/O on thread (experimental)")))->SetEnabled(!PSP_IsInited());
 	static const char *ioTimingMethods[] = { "Fast (lag on slow storage)", "Host (bugs, less lag)", "Simulate UMD delays" };
 	View *ioTimingMethod = systemSettings->Add(new PopupMultiChoice(&g_Config.iIOTimingMethod, sy->T("IO timing method"), ioTimingMethods, 0, ARRAY_SIZE(ioTimingMethods), sy->GetName(), screenManager()));