diff --git a/GPU/Common/GPUStateUtils.cpp b/GPU/Common/GPUStateUtils.cpp
index 9880fb1ee0..8fe1f13ec7 100644
--- a/GPU/Common/GPUStateUtils.cpp
+++ b/GPU/Common/GPUStateUtils.cpp
@@ -217,7 +217,7 @@ StencilValueType ReplaceAlphaWithStencilType() {
 	return STENCIL_VALUE_KEEP;
 }
 
-ReplaceBlendType ReplaceBlendWithShader(bool allowShaderBlend) {
+ReplaceBlendType ReplaceBlendWithShader(bool allowShaderBlend, GEBufferFormat bufferFormat) {
 	if (!gstate.isAlphaBlendEnabled() || gstate.isModeClear()) {
 		return REPLACE_BLEND_NO;
 	}
@@ -256,6 +256,9 @@ ReplaceBlendType ReplaceBlendWithShader(bool allowShaderBlend) {
 
 		case GE_DSTBLEND_DOUBLEDSTALPHA:
 		case GE_DSTBLEND_DOUBLEINVDSTALPHA:
+			if (bufferFormat == GE_FORMAT_565) {
+				return REPLACE_BLEND_2X_ALPHA;
+			}
 			return !allowShaderBlend ? REPLACE_BLEND_2X_ALPHA : REPLACE_BLEND_COPY_FBO;
 
 		case GE_DSTBLEND_DOUBLESRCALPHA:
@@ -276,16 +279,30 @@ ReplaceBlendType ReplaceBlendWithShader(bool allowShaderBlend) {
 		switch (funcB) {
 		case GE_DSTBLEND_SRCCOLOR:
 		case GE_DSTBLEND_INVSRCCOLOR:
+			if (bufferFormat == GE_FORMAT_565) {
+				return REPLACE_BLEND_STANDARD;
+			}
 			// Can't double, we need the source color to be correct.
 			return !allowShaderBlend ? REPLACE_BLEND_STANDARD : REPLACE_BLEND_COPY_FBO;
 
 		case GE_DSTBLEND_DOUBLEDSTALPHA:
 		case GE_DSTBLEND_DOUBLEINVDSTALPHA:
+			if (bufferFormat == GE_FORMAT_565) {
+				return REPLACE_BLEND_STANDARD;
+			}
+			return !allowShaderBlend ? REPLACE_BLEND_2X_SRC : REPLACE_BLEND_COPY_FBO;
+
 		case GE_DSTBLEND_DOUBLESRCALPHA:
 		case GE_DSTBLEND_DOUBLEINVSRCALPHA:
+			if (bufferFormat == GE_FORMAT_565) {
+				return REPLACE_BLEND_2X_ALPHA;
+			}
 			return !allowShaderBlend ? REPLACE_BLEND_2X_SRC : REPLACE_BLEND_COPY_FBO;
 
 		default:
+			if (bufferFormat == GE_FORMAT_565) {
+				return REPLACE_BLEND_STANDARD;
+			}
 			// We can't technically do this correctly (due to clamping) without reading the dst alpha.
 			return !allowShaderBlend ? REPLACE_BLEND_2X_SRC : REPLACE_BLEND_COPY_FBO;
 		}
@@ -299,6 +316,9 @@ ReplaceBlendType ReplaceBlendWithShader(bool allowShaderBlend) {
 
 		case GE_DSTBLEND_DOUBLEDSTALPHA:
 		case GE_DSTBLEND_DOUBLEINVDSTALPHA:
+			if (bufferFormat == GE_FORMAT_565) {
+				return REPLACE_BLEND_STANDARD;
+			}
 			return !allowShaderBlend ? REPLACE_BLEND_STANDARD : REPLACE_BLEND_COPY_FBO;
 
 		case GE_DSTBLEND_FIXB:
@@ -335,6 +355,9 @@ ReplaceBlendType ReplaceBlendWithShader(bool allowShaderBlend) {
 
 		case GE_DSTBLEND_DOUBLEDSTALPHA:
 		case GE_DSTBLEND_DOUBLEINVDSTALPHA:
+			if (bufferFormat == GE_FORMAT_565) {
+				return REPLACE_BLEND_STANDARD;
+			}
 			return !allowShaderBlend ? REPLACE_BLEND_STANDARD : REPLACE_BLEND_COPY_FBO;
 
 		default:
diff --git a/GPU/Common/GPUStateUtils.h b/GPU/Common/GPUStateUtils.h
index 595c8e1ae1..6acf4c7e36 100644
--- a/GPU/Common/GPUStateUtils.h
+++ b/GPU/Common/GPUStateUtils.h
@@ -1,5 +1,7 @@
 #pragma once
 
+#include "GPU/ge_constants.h"
+
 enum StencilValueType {
 	STENCIL_VALUE_UNIFORM,
 	STENCIL_VALUE_ZERO,
@@ -41,7 +43,7 @@ bool IsAlphaTestAgainstZero();
 
 StencilValueType ReplaceAlphaWithStencilType();
 ReplaceAlphaType ReplaceAlphaWithStencil(ReplaceBlendType replaceBlend);
-ReplaceBlendType ReplaceBlendWithShader(bool allowShaderBlend);
+ReplaceBlendType ReplaceBlendWithShader(bool allowShaderBlend, GEBufferFormat bufferFormat);
 
 bool CanUseHardwareTransform(int prim);
 LogicOpReplaceType ReplaceLogicOpType();
diff --git a/GPU/Common/ShaderId.cpp b/GPU/Common/ShaderId.cpp
index ecabfd848a..a528d3f983 100644
--- a/GPU/Common/ShaderId.cpp
+++ b/GPU/Common/ShaderId.cpp
@@ -209,7 +209,7 @@ void ComputeFragmentShaderID(ShaderID *id_out, uint32_t vertType) {
 		bool doTextureAlpha = gstate.isTextureAlphaUsed();
 		bool doFlatShading = gstate.getShadeMode() == GE_SHADE_FLAT;
 
-		ReplaceBlendType replaceBlend = ReplaceBlendWithShader(gstate_c.allowShaderBlend);
+		ReplaceBlendType replaceBlend = ReplaceBlendWithShader(gstate_c.allowShaderBlend, gstate.FrameBufFormat());
 		ReplaceAlphaType stencilToAlpha = ReplaceAlphaWithStencil(replaceBlend);
 
 		// All texfuncs except replace are the same for RGB as for RGBA with full alpha.
diff --git a/GPU/Directx9/StateMappingDX9.cpp b/GPU/Directx9/StateMappingDX9.cpp
index 91694b6563..5836cad112 100644
--- a/GPU/Directx9/StateMappingDX9.cpp
+++ b/GPU/Directx9/StateMappingDX9.cpp
@@ -282,7 +282,7 @@ void TransformDrawEngineDX9::ApplyBlendState() {
 	// Unfortunately, we can't really do this in Direct3D 9...
 	gstate_c.allowShaderBlend = false;
 
-	ReplaceBlendType replaceBlend = ReplaceBlendWithShader(gstate_c.allowShaderBlend);
+	ReplaceBlendType replaceBlend = ReplaceBlendWithShader(gstate_c.allowShaderBlend, gstate.FrameBufFormat());
 	ReplaceAlphaType replaceAlphaWithStencil = ReplaceAlphaWithStencil(replaceBlend);
 	bool usePreSrc = false;
 
diff --git a/GPU/GLES/StateMapping.cpp b/GPU/GLES/StateMapping.cpp
index b0e1512556..0ec7fbd4f2 100644
--- a/GPU/GLES/StateMapping.cpp
+++ b/GPU/GLES/StateMapping.cpp
@@ -324,7 +324,7 @@ void TransformDrawEngine::ApplyBlendState() {
 	// If we can't apply blending, we make a copy of the framebuffer and do it manually.
 	gstate_c.allowShaderBlend = !g_Config.bDisableSlowFramebufEffects;
 
-	ReplaceBlendType replaceBlend = ReplaceBlendWithShader(gstate_c.allowShaderBlend);
+	ReplaceBlendType replaceBlend = ReplaceBlendWithShader(gstate_c.allowShaderBlend, gstate.FrameBufFormat());
 	ReplaceAlphaType replaceAlphaWithStencil = ReplaceAlphaWithStencil(replaceBlend);
 	bool usePreSrc = false;
 
@@ -406,6 +406,21 @@ void TransformDrawEngine::ApplyBlendState() {
 	bool approxFuncB = false;
 	GLuint glBlendFuncB = blendFuncB == GE_DSTBLEND_FIXB ? blendColor2Func(fixB, approxFuncB) : bLookup[blendFuncB];
 
+	if (gstate.FrameBufFormat() == GE_FORMAT_565) {
+		if (blendFuncA == GE_SRCBLEND_DSTALPHA || blendFuncA == GE_SRCBLEND_DOUBLEDSTALPHA) {
+			glBlendFuncA = GL_ZERO;
+		}
+		if (blendFuncA == GE_SRCBLEND_INVDSTALPHA || blendFuncA == GE_SRCBLEND_DOUBLEINVDSTALPHA) {
+			glBlendFuncA = GL_ONE;
+		}
+		if (blendFuncB == GE_DSTBLEND_DSTALPHA || blendFuncB == GE_DSTBLEND_DOUBLEDSTALPHA) {
+			glBlendFuncB = GL_ZERO;
+		}
+		if (blendFuncB == GE_DSTBLEND_INVDSTALPHA || blendFuncB == GE_DSTBLEND_DOUBLEINVDSTALPHA) {
+			glBlendFuncB = GL_ONE;
+		}
+	}
+
 	if (usePreSrc) {
 		glBlendFuncA = GL_ONE;
 		// Need to pull in the fixed color.