diff --git a/Common/GPU/Shader.h b/Common/GPU/Shader.h
index ae06e9248e..018d2bf98e 100644
--- a/Common/GPU/Shader.h
+++ b/Common/GPU/Shader.h
@@ -97,6 +97,7 @@ struct UniformDef {
 
 enum class SamplerFlags {
 	ARRAY_ON_VULKAN = 1,
+	MULTISAMPLE = 2,  // Only supported on Vulkan, read with texelFetch.
 };
 ENUM_CLASS_BITOPS(SamplerFlags);
 
diff --git a/Common/GPU/ShaderWriter.cpp b/Common/GPU/ShaderWriter.cpp
index 4d6df0b476..224ee4ca0e 100644
--- a/Common/GPU/ShaderWriter.cpp
+++ b/Common/GPU/ShaderWriter.cpp
@@ -391,7 +391,9 @@ void ShaderWriter::DeclareTexture2D(const SamplerDef &def) {
 		break;
 	case GLSL_VULKAN:
 		// texBindingBase_ is used for the thin3d descriptor set layout, where they start at 1.
-		if (def.flags & SamplerFlags::ARRAY_ON_VULKAN) {
+		if (def.flags & SamplerFlags::MULTISAMPLE) {
+			F("layout(set = 0, binding = %d) uniform sampler2DMS%s %s;\n", def.binding + texBindingBase_, (def.flags & SamplerFlags::ARRAY_ON_VULKAN) ? "Array" : "", def.name);
+		} else if (def.flags & SamplerFlags::ARRAY_ON_VULKAN) {
 			F("layout(set = 0, binding = %d) uniform sampler2DArray %s;\n", def.binding + texBindingBase_, def.name);
 		} else {
 			F("layout(set = 0, binding = %d) uniform sampler2D %s;\n", def.binding + texBindingBase_, def.name);
diff --git a/Common/GPU/Vulkan/VulkanFramebuffer.cpp b/Common/GPU/Vulkan/VulkanFramebuffer.cpp
index da0d06311c..9a95f9bcbf 100644
--- a/Common/GPU/Vulkan/VulkanFramebuffer.cpp
+++ b/Common/GPU/Vulkan/VulkanFramebuffer.cpp
@@ -178,7 +178,8 @@ void VKRFramebuffer::CreateImage(VulkanContext *vulkan, VulkanBarrierBatch *barr
 	ici.tiling = VK_IMAGE_TILING_OPTIMAL;
 	ici.format = format;
 	ici.usage = VK_IMAGE_USAGE_TRANSFER_DST_BIT | VK_IMAGE_USAGE_TRANSFER_SRC_BIT;
-	if (sampleCount == VK_SAMPLE_COUNT_1_BIT) {
+	// Multisampled color is sampled too, to read single samples where averaging them would be wrong.
+	if (sampleCount == VK_SAMPLE_COUNT_1_BIT || color) {
 		ici.usage |= VK_IMAGE_USAGE_SAMPLED_BIT;
 	}
 	if (color) {
diff --git a/Common/GPU/Vulkan/VulkanQueueRunner.cpp b/Common/GPU/Vulkan/VulkanQueueRunner.cpp
index d51997dbb6..f28069f19c 100644
--- a/Common/GPU/Vulkan/VulkanQueueRunner.cpp
+++ b/Common/GPU/Vulkan/VulkanQueueRunner.cpp
@@ -989,7 +989,11 @@ void VulkanQueueRunner::LogReadbackImage(const VKRStep &step) {
 void VulkanQueueRunner::PerformRenderPass(const VKRStep &step, VkCommandBuffer cmd, const int curFrame, QueueProfileContext &profile) {
 	for (size_t i = 0; i < step.preTransitions.size(); i++) {
 		const TransitionRequest &iter = step.preTransitions[i];
-		if (iter.aspect == VK_IMAGE_ASPECT_COLOR_BIT && iter.fb->color.layout != iter.targetLayout) {
+		if (iter.samples) {
+			if (iter.fb->msaaColor.image != VK_NULL_HANDLE && iter.fb->msaaColor.layout != iter.targetLayout) {
+				recordBarrier_.TransitionColorImageAuto(&iter.fb->msaaColor, iter.targetLayout);
+			}
+		} else if (iter.aspect == VK_IMAGE_ASPECT_COLOR_BIT && iter.fb->color.layout != iter.targetLayout) {
 			recordBarrier_.TransitionColorImageAuto(
 				&iter.fb->color,
 				iter.targetLayout
@@ -1341,6 +1345,10 @@ VKRRenderPass *VulkanQueueRunner::PerformBindFramebufferAsRenderTarget(const VKR
 		}
 
 		recordBarrier_.TransitionColorImageAuto(&fb->color, VK_IMAGE_LAYOUT_COLOR_ATTACHMENT_OPTIMAL);
+		if (fb->msaaColor.image != VK_NULL_HANDLE) {
+			// Texturing from the samples (BindFramebufferAsTexture) moves this one out of the attachment layout.
+			recordBarrier_.TransitionColorImageAuto(&fb->msaaColor, VK_IMAGE_LAYOUT_COLOR_ATTACHMENT_OPTIMAL);
+		}
 
 		// If the render pass doesn't touch depth, we can avoid a layout transition of the depth buffer.
 		if (fb->depth.image && RenderPassTypeHasDepth(step.render.renderPassType)) {
diff --git a/Common/GPU/Vulkan/VulkanQueueRunner.h b/Common/GPU/Vulkan/VulkanQueueRunner.h
index eea23961cf..3a83bf583e 100644
--- a/Common/GPU/Vulkan/VulkanQueueRunner.h
+++ b/Common/GPU/Vulkan/VulkanQueueRunner.h
@@ -129,9 +129,10 @@ struct TransitionRequest {
 	VKRFramebuffer *fb;
 	VkImageAspectFlags aspect;  // COLOR or DEPTH
 	VkImageLayout targetLayout;
+	bool samples = false;  // The multisampled color image, instead of the resolved one.
 
 	bool operator == (const TransitionRequest &other) const {
-		return fb == other.fb && aspect == other.aspect && targetLayout == other.targetLayout;
+		return fb == other.fb && aspect == other.aspect && targetLayout == other.targetLayout && samples == other.samples;
 	}
 };
 
diff --git a/Common/GPU/Vulkan/VulkanRenderManager.cpp b/Common/GPU/Vulkan/VulkanRenderManager.cpp
index 12aad52aa3..a1c2286b53 100644
--- a/Common/GPU/Vulkan/VulkanRenderManager.cpp
+++ b/Common/GPU/Vulkan/VulkanRenderManager.cpp
@@ -1550,7 +1550,7 @@ void VulkanRenderManager::BlitFramebuffer(VKRFramebuffer *src, VkRect2D srcRect,
 	steps_.push_back(step);
 }
 
-VkImageView VulkanRenderManager::BindFramebufferAsTexture(VKRFramebuffer *fb, int binding, VkImageAspectFlags aspectBit, int layer) {
+VkImageView VulkanRenderManager::BindFramebufferAsTexture(VKRFramebuffer *fb, int binding, VkImageAspectFlags aspectBit, int layer, bool samples) {
 	_dbg_assert_(curRenderStep_ != nullptr);
 	_dbg_assert_(fb != nullptr);
 
@@ -1558,6 +1558,13 @@ VkImageView VulkanRenderManager::BindFramebufferAsTexture(VKRFramebuffer *fb, in
 	_dbg_assert_(aspectBit == VK_IMAGE_ASPECT_COLOR_BIT || aspectBit == VK_IMAGE_ASPECT_DEPTH_BIT);
 
 	// Mark the dependency, check for required transitions, and return the image.
+	if (samples && fb->msaaColor.image != VK_NULL_HANDLE) {
+		_dbg_assert_(aspectBit == VK_IMAGE_ASPECT_COLOR_BIT);
+		curRenderStep_->dependencies.insert(fb);
+		TransitionRequest rq{ fb, aspectBit, VK_IMAGE_LAYOUT_SHADER_READ_ONLY_OPTIMAL, true };
+		curRenderStep_->preTransitions.insert(rq);
+		return layer == -1 ? fb->msaaColor.texAllLayersView : fb->msaaColor.texLayerViews[layer];
+	}
 
 	// Optimization: If possible, use final*Layout to put the texture into the correct layout "early".
 	for (int i = (int)steps_.size() - 1; i >= 0; i--) {
diff --git a/Common/GPU/Vulkan/VulkanRenderManager.h b/Common/GPU/Vulkan/VulkanRenderManager.h
index d8df63f634..e990c157e8 100644
--- a/Common/GPU/Vulkan/VulkanRenderManager.h
+++ b/Common/GPU/Vulkan/VulkanRenderManager.h
@@ -270,7 +270,8 @@ public:
 	// as the other backends, even though there's no actual binding happening here.
 	// For layer, we use the same convention as thin3d, where layer = -1 means all layers together. For texturing, that means that you
 	// get an array texture view.
-	VkImageView BindFramebufferAsTexture(VKRFramebuffer *fb, int binding, VkImageAspectFlags aspectBits, int layer);
+	// With samples, binds the multisampled color image (for texelFetch of single samples) instead of the resolved one.
+	VkImageView BindFramebufferAsTexture(VKRFramebuffer *fb, int binding, VkImageAspectFlags aspectBits, int layer, bool samples = false);
 
 	bool CopyFramebufferToMemory(VKRFramebuffer *src, VkImageAspectFlags aspectBits, int x, int y, int w, int h, Draw::DataFormat destFormat, uint8_t *pixels, int pixelStride, Draw::ReadbackMode mode, const char *tag);
 	void CopyImageToMemorySync(VkImage image, int mipLevel, int x, int y, int w, int h, Draw::DataFormat destFormat, uint8_t *pixels, int pixelStride, const char *tag);
diff --git a/Common/GPU/Vulkan/thin3d_vulkan.cpp b/Common/GPU/Vulkan/thin3d_vulkan.cpp
index 9e28c5a92a..9cb178a646 100644
--- a/Common/GPU/Vulkan/thin3d_vulkan.cpp
+++ b/Common/GPU/Vulkan/thin3d_vulkan.cpp
@@ -460,6 +460,7 @@ public:
 	// These functions should be self explanatory.
 	void BindFramebufferAsRenderTarget(Framebuffer *fbo, const RenderPassInfo &rp, const char *tag) override;
 	void BindFramebufferAsTexture(Framebuffer *fbo, int binding, Aspect channelBit, int layer) override;
+	void BindFramebufferSamplesAsTexture(Framebuffer *fbo, int binding, int layer) override;
 
 	void GetFramebufferDimensions(Framebuffer *fbo, int *w, int *h) override;
 
@@ -973,7 +974,8 @@ VKContext::VKContext(VulkanContext *vulkan, bool useRenderThread)
 	caps_.framebufferDepthBlitSupported = vulkan->GetDeviceInfo().canBlitToPreferredDepthStencilFormat;
 	caps_.framebufferStencilBlitSupported = caps_.framebufferDepthBlitSupported;
 	caps_.framebufferDepthCopySupported = true;   // Will pretty much always be the case.
-	caps_.framebufferSeparateDepthCopySupported = true;   // Will pretty much always be the case.
+	caps_.framebufferSeparateDepthCopySupported = true;
+	caps_.framebufferSampleReadSupported = true;   // Will pretty much always be the case.
 	// This doesn't affect what depth/stencil format is actually used, see VulkanQueueRunner.
 	caps_.preferredDepthBufferFormat = DataFormatFromVulkanDepth(vulkan->GetDeviceInfo().preferredDepthStencilFormat);
 	caps_.texture3DSupported = true;
@@ -1952,6 +1954,14 @@ void VKContext::BindFramebufferAsTexture(Framebuffer *fbo, int binding, Aspect c
 	boundImageView_[binding] = renderManager_.BindFramebufferAsTexture(fb->GetFB(), binding, aspect, layer);
 }
 
+void VKContext::BindFramebufferSamplesAsTexture(Framebuffer *fbo, int binding, int layer) {
+	VKFramebuffer *fb = (VKFramebuffer *)fbo;
+	_assert_(binding >= 0 && binding < MAX_BOUND_TEXTURES);
+	_assert_(fb != curFramebuffer_);
+	boundTextures_[binding].reset(nullptr);
+	boundImageView_[binding] = renderManager_.BindFramebufferAsTexture(fb->GetFB(), binding, VK_IMAGE_ASPECT_COLOR_BIT, layer, true);
+}
+
 void VKContext::GetFramebufferDimensions(Framebuffer *fbo, int *w, int *h) {
 	VKFramebuffer *fb = (VKFramebuffer *)fbo;
 	if (fb) {
diff --git a/Common/GPU/thin3d.h b/Common/GPU/thin3d.h
index 75edf35f92..dd248f2970 100644
--- a/Common/GPU/thin3d.h
+++ b/Common/GPU/thin3d.h
@@ -608,6 +608,7 @@ struct DeviceCaps {
 	bool framebufferBlitSupported;
 	bool framebufferDepthCopySupported;
 	bool framebufferSeparateDepthCopySupported;
+	bool framebufferSampleReadSupported = false;  // BindFramebufferSamplesAsTexture works.
 	bool framebufferDepthBlitSupported;
 	bool framebufferStencilBlitSupported;
 	bool framebufferFetchSupported;
@@ -824,6 +825,9 @@ public:
 
 	// binding must be < MAX_TEXTURE_SLOTS (0, 1 are okay if it's 2).
 	virtual void BindFramebufferAsTexture(Framebuffer *fbo, int binding, Aspect aspect, int layer) = 0;
+	// Binds a multisampled framebuffer's color samples, for texelFetch from a sampler with SamplerFlags::MULTISAMPLE.
+	// Check framebufferSampleReadSupported.
+	virtual void BindFramebufferSamplesAsTexture(Framebuffer *fbo, int binding, int layer) {}
 
 	// Framebuffer fetch / input attachment support, needs to be explicit in Vulkan.
 	virtual void BindCurrentFramebufferForColorInput() {}
diff --git a/Core/CmdLine.cpp b/Core/CmdLine.cpp
index 4c8fca4178..41ca3ea086 100644
--- a/Core/CmdLine.cpp
+++ b/Core/CmdLine.cpp
@@ -233,6 +233,7 @@ static const CommandLineParam g_autoParams[] = {
 	{POFF(odsLog), CmdParamType::Bool, "odslog", 'o', "Also log through OutputDebugString (Windows)", CmdLineMode::Headless},
 	{POFF(generateInterpreterDispatch), CmdParamType::Bool, "generate-interpreter-dispatch", '\0', "Generate C++ interpreter dispatch code (ExecInstruction) to stdout and exit", CmdLineMode::Headless},
 	{POFF(resolutionScale), CmdParamType::Int, "resolution-scale", '\0', "Set the resolution scale factor"},
+	{POFF(msaa), CmdParamType::Int, "msaa", '\0', "Set the MSAA level (0 = off, 1 = 2x, 2 = 4x, 3 = 8x)"},
 	{POFF(debuggerPort), CmdParamType::Int, "debugger", '\0', "Enable the WebSocket debugger on this port (0 = pick automatically); see docs/WebSocketDebugger.md"},
 	{POFF(debuggerRunPort), CmdParamType::Int, "debugger-run", '\0', "Like --debugger, but starts running instead of waiting at the entry point", CmdLineMode::Headless},
 	{POFF(autoSaveLoadSymbols), CmdParamType::Bool, "auto-save-load-symbols", '\0', "Auto save/load per-module and per-game symbol files (see bAutoSaveLoadSymbols)", CmdLineMode::Both},
@@ -617,6 +618,11 @@ void CommandLineOptions::ApplyToConfig() const {
 		g_Config.DoNotSaveSetting(&g_Config.iInternalResolution);
 	}
 
+	if (msaa.has_value()) {
+		g_Config.iMultiSampleLevel = msaa.value();
+		g_Config.DoNotSaveSetting(&g_Config.iMultiSampleLevel);
+	}
+
 	if (memReadAction.has_value()) {
 		g_Config.iExceptionActionMemRead = memReadAction.value();
 		g_Config.DoNotSaveSetting(&g_Config.iExceptionActionMemRead);
diff --git a/Core/CmdLine.h b/Core/CmdLine.h
index 4df2726356..2d7b160787 100644
--- a/Core/CmdLine.h
+++ b/Core/CmdLine.h
@@ -160,6 +160,7 @@ struct CommandLineOptions {
 
 	// Headless options that may also be mildly useful in application mode
 	std::optional<int> resolutionScale;
+	std::optional<int> msaa;
 
 
 	// Headless options
diff --git a/GPU/Common/Draw2D.cpp b/GPU/Common/Draw2D.cpp
index 06b7fa4bce..80f3f2a68e 100644
--- a/GPU/Common/Draw2D.cpp
+++ b/GPU/Common/Draw2D.cpp
@@ -69,6 +69,27 @@ Draw2DPipelineInfo GenerateDraw2DCopyColorFs(ShaderWriter &writer) {
 	};
 }
 
+static const SamplerDef samplersMS[1] = {
+	{ 0, "tex", SamplerFlags::ARRAY_ON_VULKAN | SamplerFlags::MULTISAMPLE },
+};
+
+// Source and destination are the same size, so the fragment coordinate is the texel.
+Draw2DPipelineInfo GenerateDraw2DCopyColorSample0Fs(ShaderWriter &writer) {
+	writer.DeclareSamplers(samplersMS);
+	writer.BeginFSMain(Slice<UniformDef>::empty(), varyings);
+	writer.C("  vec4 outColor = texelFetch(tex, ivec3(ivec2(gl_FragCoord.xy), 0), 0);\n");
+	writer.EndFSMain("outColor");
+
+	Draw2DPipelineInfo info{
+		"draw2d_copy_color_sample0",
+		RASTER_COLOR,
+		RASTER_COLOR,
+		samplersMS,
+	};
+	info.readSamples = true;
+	return info;
+}
+
 Draw2DPipelineInfo GenerateDraw2DCopyColorRect2LinFs(ShaderWriter &writer) {
 	writer.DeclareSamplers(samplers);
 	writer.BeginFSMain(g_draw2Duniforms, varyings);
@@ -374,6 +395,16 @@ Draw2DPipeline *FramebufferManagerCommon::Get2DPipeline(Draw2DShader shader) {
 		}
 		pipeline = draw2DPipelineColorRect2Lin_;
 		break;
+
+	case DRAW2D_COPY_COLOR_SAMPLE0:
+		if (!draw_->GetDeviceCaps().framebufferSampleReadSupported) {
+			return nullptr;
+		}
+		if (!draw2DPipelineColorSample0_) {
+			draw2DPipelineColorSample0_ = draw2D_.Create2DPipeline(&GenerateDraw2DCopyColorSample0Fs);
+		}
+		pipeline = draw2DPipelineColorSample0_;
+		break;
 	case DRAW2D_COPY_DEPTH:
 		if (!draw_->GetDeviceCaps().fragmentShaderDepthWriteSupported) {
 			// Can't do it
diff --git a/GPU/Common/Draw2D.h b/GPU/Common/Draw2D.h
index 076d319957..a311cf06db 100644
--- a/GPU/Common/Draw2D.h
+++ b/GPU/Common/Draw2D.h
@@ -20,6 +20,7 @@ enum Draw2DShader {
 	DRAW2D_565_TO_DEPTH,
 	DRAW2D_565_TO_DEPTH_DESWIZZLE,
 	DRAW2D_COPY_COLOR_RECT2LIN,
+	DRAW2D_COPY_COLOR_SAMPLE0,  // From a multisampled framebuffer, its first sample instead of the average. Needs framebufferSampleReadSupported.
 };
 
 inline RasterChannel Draw2DSourceChannel(Draw2DShader shader) {
@@ -40,6 +41,7 @@ struct Draw2DPipelineInfo {
 	RasterChannel readChannel;
 	RasterChannel writeChannel;
 	Slice<SamplerDef> samplers;
+	bool readSamples = false;  // Binds the source with BindFramebufferSamplesAsTexture.
 };
 
 extern const UniformDef g_draw2Duniforms[2];
diff --git a/GPU/Common/FragmentShaderGenerator.cpp b/GPU/Common/FragmentShaderGenerator.cpp
index 65954fc2ec..36305007c3 100644
--- a/GPU/Common/FragmentShaderGenerator.cpp
+++ b/GPU/Common/FragmentShaderGenerator.cpp
@@ -217,13 +217,15 @@ bool GenerateFragmentShader(const FShaderID &id, char *buffer, const ShaderLangu
 		}
 
 		// Note: the precision qualifiers must match the vertex shader!
-		WRITE(p, "layout (location = 1) %s in lowp vec4 v_color0;\n", shading);
+		// Centroid, matching the vertex shader.
+		const char *colorQualifier = *shading ? shading : "centroid";
+		WRITE(p, "layout (location = 1) %s in lowp vec4 v_color0;\n", colorQualifier);
 		if (lmode) {
-			WRITE(p, "layout (location = 2) %s in lowp vec3 v_color1;\n", shading);
+			WRITE(p, "layout (location = 2) %s in lowp vec3 v_color1;\n", colorQualifier);
 		}
 		WRITE(p, "layout (location = 3) in highp float v_fogdepth;\n");
 		if (doTexture) {
-			WRITE(p, "layout (location = 0) in highp vec3 v_texcoord;\n");
+			WRITE(p, "layout (location = 0) centroid in highp vec3 v_texcoord;\n");
 		}
 		if (fsMinmaxDiscard || fsDepthClamp) {
 			WRITE(p, "layout (location = 4) in highp vec2 v_zw;\n");
diff --git a/GPU/Common/FramebufferManagerCommon.cpp b/GPU/Common/FramebufferManagerCommon.cpp
index d24dc00018..269f8cffe4 100644
--- a/GPU/Common/FramebufferManagerCommon.cpp
+++ b/GPU/Common/FramebufferManagerCommon.cpp
@@ -1053,8 +1053,12 @@ void FramebufferManagerCommon::BlitFramebufferDepth(VirtualFramebuffer *src, Vir
 void FramebufferManagerCommon::CopyDepthRect(Draw::Framebuffer *src, int srcX, int srcY, Draw::Framebuffer *dst, int dstX, int dstY, int w, int h, int scaleFactor, const char *tag) {
 	const Draw::DeviceCaps &caps = draw_->GetDeviceCaps();
 	const bool sameSamples = src->MultiSampleLevel() == dst->MultiSampleLevel();
-	if (sameSamples && (caps.framebufferSeparateDepthCopySupported || (!caps.framebufferDepthBlitSupported && caps.framebufferCopySupported))) {
+	// Only a copy takes all the samples, and blits of multisampled buffers aren't supported at all.
+	const bool multisampled = src->MultiSampleLevel() != 0 || dst->MultiSampleLevel() != 0;
+	if (sameSamples && (caps.framebufferSeparateDepthCopySupported || (!caps.framebufferDepthBlitSupported && caps.framebufferCopySupported) || (multisampled && caps.framebufferCopySupported))) {
 		draw_->CopyFramebufferImage(src, 0, srcX, srcY, 0, dst, 0, dstX, dstY, 0, w, h, 1, Draw::Aspect::DEPTH_BIT, tag);
+	} else if (multisampled) {
+		WARN_LOG_ONCE(depthRectMSAA, Log::FrameBuf, "Can't copy multisampled depth here (%s)", tag);
 	} else if (caps.framebufferDepthBlitSupported) {
 		draw_->BlitFramebuffer(src, srcX, srcY, srcX + w, srcY + h, dst, dstX, dstY, dstX + w, dstY + h, Draw::Aspect::DEPTH_BIT, Draw::FB_BLIT_NEAREST, tag);
 	} else if (caps.fragmentShaderDepthWriteSupported && caps.textureDepthSupported) {
@@ -3076,11 +3080,33 @@ static const char *TempFBOReasonToString(TempFBO reason) {
 	case TempFBO::COPY: return "copy";
 	case TempFBO::STENCIL: return "stencil";
 	case TempFBO::DEPTH_SHIFT: return "depth_shift";
+	case TempFBO::SAMPLE0: return "sample0";
 	default: break;
 	}
 	return "";
 }
 
+Draw::Framebuffer *FramebufferManagerCommon::CopyColorSample0(VirtualFramebuffer *vfb) {
+	if (!vfb->fbo || vfb->fbo->MultiSampleLevel() == 0) {
+		return nullptr;
+	}
+	Draw2DPipeline *pipeline = Get2DPipeline(DRAW2D_COPY_COLOR_SAMPLE0);
+	if (!pipeline) {
+		return nullptr;
+	}
+	const int w = vfb->fbo->Width();
+	const int h = vfb->fbo->Height();
+	Draw::Framebuffer *copy = GetTempFBO(TempFBO::SAMPLE0, w, h);
+	if (!copy) {
+		return nullptr;
+	}
+	BlitUsingRaster(vfb->fbo, 0.0f, 0.0f, w, h, copy, 0.0f, 0.0f, w, h, false, vfb->renderScaleFactor, pipeline, "CopyColorSample0");
+	draw_->Invalidate(InvalidationFlags::CACHED_RENDER_STATE);
+	gstate_c.Dirty(DIRTY_ALL_RENDER_STATE);
+	RebindFramebuffer("After CopyColorSample0");
+	return copy;
+}
+
 Draw::Framebuffer *FramebufferManagerCommon::GetTempFBO(TempFBO reason, u16 w, u16 h) {
 	u64 key = ((u64)reason << 48) | ((u32)w << 16) | h;
 	auto it = tempFBOs_.find(key);
@@ -3090,10 +3116,12 @@ Draw::Framebuffer *FramebufferManagerCommon::GetTempFBO(TempFBO reason, u16 w, u
 	}
 
 	bool z_stencil = reason == TempFBO::STENCIL || reason == TempFBO::DEPTH_SHIFT;
+	// The depth shift copies to and from a framebuffer, which needs the same samples.
+	const int msaaLevel = reason == TempFBO::DEPTH_SHIFT ? msaaLevel_ : 0;
 	char name[128];
 	snprintf(name, sizeof(name), "tempfbo_%s_%dx%d", TempFBOReasonToString(reason), w / renderScaleFactor_, h / renderScaleFactor_);
 
-	Draw::Framebuffer *fbo = draw_->CreateFramebuffer({ w, h, 1, GetFramebufferLayers(), 0, z_stencil, name });
+	Draw::Framebuffer *fbo = draw_->CreateFramebuffer({ w, h, 1, GetFramebufferLayers(), msaaLevel, z_stencil, name });
 	if (!fbo) {
 		return nullptr;
 	}
@@ -3538,6 +3566,7 @@ void FramebufferManagerCommon::ReleasePipelines() {
 	DoRelease(depthReadbackPipeline_);
 	DoRelease(draw2DPipelineCopyColor_);
 	DoRelease(draw2DPipelineColorRect2Lin_);
+	DoRelease(draw2DPipelineColorSample0_);
 	DoRelease(draw2DPipelineCopyDepth_);
 	DoRelease(draw2DPipelineEncodeDepth_);
 	DoRelease(draw2DPipeline565ToDepth_);
@@ -3654,6 +3683,11 @@ void FramebufferManagerCommon::BlitFramebuffer(VirtualFramebuffer *dst, int dstX
 		useBlit = false;
 		useCopy = false;
 	}
+	// Copy depth where we can: a raster copy isn't exact (Burnout Dominator's recursive rendering, #11100), and with
+	// multisampling it reads the single-sampled depth, which is never resolved, while a copy takes all the samples.
+	if (channel == RASTER_DEPTH && src != dst && src->fbo->MultiSampleLevel() == dst->fbo->MultiSampleLevel() && draw_->GetDeviceCaps().framebufferSeparateDepthCopySupported) {
+		useCopy = true;
+	}
 
 	float srcXFactor = src->renderScaleFactor;
 	float srcYFactor = src->renderScaleFactor;
@@ -3749,7 +3783,11 @@ void FramebufferManagerCommon::BlitUsingRaster(
 	draw_->BindTexture(0, nullptr);
 	// This will get optimized away in case it's already bound (in VK and GL at least..)
 	draw_->BindFramebufferAsRenderTarget(dest, { Draw::RPAction::KEEP, Draw::RPAction::KEEP, Draw::RPAction::KEEP }, tag ? tag : "BlitUsingRaster");
-	draw_->BindFramebufferAsTexture(src, 0, pipeline->info.readChannel == RASTER_COLOR ? Draw::Aspect::COLOR_BIT : Draw::Aspect::DEPTH_BIT, Draw::ALL_LAYERS);
+	if (pipeline->info.readSamples) {
+		draw_->BindFramebufferSamplesAsTexture(src, 0, Draw::ALL_LAYERS);
+	} else {
+		draw_->BindFramebufferAsTexture(src, 0, pipeline->info.readChannel == RASTER_COLOR ? Draw::Aspect::COLOR_BIT : Draw::Aspect::DEPTH_BIT, Draw::ALL_LAYERS);
+	}
 
 	if (destX1 == 0.0f && destY1 == 0.0f && destX2 >= destW && destY2 >= destH) {
 		// We overwrite the whole channel of the framebuffer, so we can invalidate the current contents.
diff --git a/GPU/Common/FramebufferManagerCommon.h b/GPU/Common/FramebufferManagerCommon.h
index 596b04f26e..3f09413277 100644
--- a/GPU/Common/FramebufferManagerCommon.h
+++ b/GPU/Common/FramebufferManagerCommon.h
@@ -233,6 +233,8 @@ enum class TempFBO {
 	STENCIL,
 	// Depth moved within one framebuffer, for rendering at an X offset.
 	DEPTH_SHIFT,
+	// The first samples of a multisampled framebuffer.
+	SAMPLE0,
 };
 
 inline Draw::DataFormat GEFormatToThin3D(GEBufferFormat geFormat) {
@@ -460,6 +462,9 @@ public:
 	virtual void DeviceRestore(Draw::DrawContext *draw);
 
 	Draw::Framebuffer *GetTempFBO(TempFBO reason, u16 w, u16 h);
+	// A single-sampled copy of the first sample of each pixel of a multisampled framebuffer, or null if it isn't
+	// multisampled or the backend can't. For reading colors as values, which averaging the samples would corrupt.
+	Draw::Framebuffer *CopyColorSample0(VirtualFramebuffer *vfb);
 
 	// Debug features
 	virtual bool GetFramebuffer(u32 fb_address, int fb_stride, GEBufferFormat format, GPUDebugBuffer &buffer, int maxRes);
@@ -675,6 +680,7 @@ protected:
 	// Draw2D pipelines
 	Draw2DPipeline *draw2DPipelineCopyColor_ = nullptr;
 	Draw2DPipeline *draw2DPipelineColorRect2Lin_ = nullptr;
+	Draw2DPipeline *draw2DPipelineColorSample0_ = nullptr;
 	Draw2DPipeline *draw2DPipelineCopyDepth_ = nullptr;
 	Draw2DPipeline *draw2DPipelineEncodeDepth_ = nullptr;
 	Draw2DPipeline *draw2DPipeline565ToDepth_ = nullptr;
diff --git a/GPU/Common/TextureCacheCommon.cpp b/GPU/Common/TextureCacheCommon.cpp
index 0ffb3a2b16..2841d326b0 100644
--- a/GPU/Common/TextureCacheCommon.cpp
+++ b/GPU/Common/TextureCacheCommon.cpp
@@ -2479,6 +2479,8 @@ void TextureCacheCommon::ApplyTextureFramebuffer(VirtualFramebuffer *framebuffer
 	bool smoothedDepal = false;
 	u32 depthUpperBits = 0;
 
+	VirtualFramebuffer sample0Vfb;
+
 	if (need_depalettize) {
 		if (clutRenderAddress_ == 0xFFFFFFFF) {
 			clutTexture = clutTextureCache_.GetClutTexture(clutFormat, clutHash_, clutBufRaw_);
@@ -2495,6 +2497,17 @@ void TextureCacheCommon::ApplyTextureFramebuffer(VirtualFramebuffer *framebuffer
 			framebufferManager_->BlitUsingRaster(dynamicClutTemp_, 0.0f, 0.0f, 512.0f, 1.0f, dynamicClutFbo_, 0.0f, 0.0f, scaleFactorX * 512.0f, 1.0f, false, 1.0f, reinterpret, "reinterpret_clut");
 		}
 
+		// With multisampling, take one sample instead of the average, since the colors are looked up as indices.
+		// Dragon Ball Z: Tenkaichi Tag Team's outlines look up its framebuffer as CLUT32. (A smooth color grade
+		// loses its antialiasing this way, but that's the smaller loss.)
+		if (!depth) {
+			if (Draw::Framebuffer *sample0 = framebufferManager_->CopyColorSample0(framebuffer)) {
+				sample0Vfb = *framebuffer;
+				sample0Vfb.fbo = sample0;
+				framebuffer = &sample0Vfb;
+			}
+		}
+
 		if (useShaderDepal) {
 			_dbg_assert_(!depth);
 
diff --git a/GPU/Common/VertexShaderGenerator.cpp b/GPU/Common/VertexShaderGenerator.cpp
index 8d27eaa676..ed5025a6d7 100644
--- a/GPU/Common/VertexShaderGenerator.cpp
+++ b/GPU/Common/VertexShaderGenerator.cpp
@@ -203,12 +203,15 @@ bool GenerateVertexShader(const VShaderID &id, char *buffer, const ShaderLanguag
 				WRITE(p, "layout (location = %d) in vec3 color1;\n", (int)PspAttributeLocation::COLOR1);
 		}
 
-		WRITE(p, "layout (location = 1) %sout lowp vec4 v_color0;\n", shading);
+		// Centroid keeps them inside the primitive on pixels it only partly covers with MSAA, so that
+		// textures aren't sampled from outside the UV range. Without MSAA, it's the same as center.
+		const char *colorQualifier = *shading ? shading : "centroid ";
+		WRITE(p, "layout (location = 1) %sout lowp vec4 v_color0;\n", colorQualifier);
 		if (lmode) {
-			WRITE(p, "layout (location = 2) %sout lowp vec3 v_color1;\n", shading);
+			WRITE(p, "layout (location = 2) %sout lowp vec3 v_color1;\n", colorQualifier);
 		}
 
-		WRITE(p, "layout (location = 0) out highp vec3 v_texcoord;\n");
+		WRITE(p, "layout (location = 0) centroid out highp vec3 v_texcoord;\n");
 
 		WRITE(p, "layout (location = 3) out highp float v_fogdepth;\n");