diff --git a/Core/Config.cpp b/Core/Config.cpp
index be9dcf77a7..1c0f821b30 100644
--- a/Core/Config.cpp
+++ b/Core/Config.cpp
@@ -613,7 +613,6 @@ static ConfigSetting graphicsSettings[] = {
 	ConfigSetting("SoftwareRenderer", &g_Config.bSoftwareRendering, false, true, true),
 	ReportedConfigSetting("HardwareTransform", &g_Config.bHardwareTransform, true, true, true),
 	ReportedConfigSetting("SoftwareSkinning", &g_Config.bSoftwareSkinning, true, true, true),
-	ConfigSetting("ShaderDepal", &g_Config.bShaderDepal, false, true, true),
 	ReportedConfigSetting("TextureFiltering", &g_Config.iTexFiltering, 1, true, true),
 	ReportedConfigSetting("BufferFiltering", &g_Config.iBufFilter, SCALE_LINEAR, true, true),
 	ReportedConfigSetting("InternalResolution", &g_Config.iInternalResolution, &DefaultInternalResolution, true, true),
diff --git a/Core/Config.h b/Core/Config.h
index 66a0d4694e..b5f25bdf4a 100644
--- a/Core/Config.h
+++ b/Core/Config.h
@@ -139,7 +139,6 @@ public:
 	bool bSoftwareRendering;
 	bool bHardwareTransform; // only used in the GLES backend
 	bool bSoftwareSkinning;  // may speed up some games
-	bool bShaderDepal;
 	bool bVendorBugChecksEnabled;
 
 	int iRenderingMode; // 0 = non-buffered rendering 1 = buffered rendering
diff --git a/GPU/GLES/TextureCacheGLES.cpp b/GPU/GLES/TextureCacheGLES.cpp
index 4c2ba52c49..9e4bfe793a 100644
--- a/GPU/GLES/TextureCacheGLES.cpp
+++ b/GPU/GLES/TextureCacheGLES.cpp
@@ -442,10 +442,7 @@ protected:
 void TextureCacheGLES::ApplyTextureFramebuffer(TexCacheEntry *entry, VirtualFramebuffer *framebuffer) {
 	DepalShader *depal = nullptr;
 	uint32_t clutMode = gstate.clutformat & 0xFFFFFF;
-	bool useShaderDepal = false;
-	if (g_Config.bShaderDepal) {
-		useShaderDepal = framebufferManager_->GetCurrentRenderVFB() != framebuffer && gstate_c.Supports(GPU_SUPPORTS_GLSL_ES_300);
-	}
+	bool useShaderDepal = framebufferManager_->GetCurrentRenderVFB() != framebuffer && gstate_c.Supports(GPU_SUPPORTS_GLSL_ES_300);
 
 	if ((entry->status & TexCacheEntry::STATUS_DEPALETTIZE) && !g_Config.bDisableSlowFramebufEffects) {
 		if (useShaderDepal) {
diff --git a/UI/GameSettingsScreen.cpp b/UI/GameSettingsScreen.cpp
index 1653296d12..58bd46732f 100644
--- a/UI/GameSettingsScreen.cpp
+++ b/UI/GameSettingsScreen.cpp
@@ -375,11 +375,6 @@ void GameSettingsScreen::CreateViews() {
 		});
 		swSkin->SetDisabledPtr(&g_Config.bSoftwareRendering);
 
-		if (g_Config.iGPUBackend == (int)GPUBackend::OPENGL) {
-			CheckBox *shaderDepal = graphicsSettings->Add(new CheckBox(&g_Config.bShaderDepal, gr->T("Shader Depal")));
-			shaderDepal->SetDisabledPtr(&g_Config.bSoftwareRendering);
-		}
-		
 		CheckBox *vtxCache = graphicsSettings->Add(new CheckBox(&g_Config.bVertexCache, gr->T("Vertex Cache")));
 		vtxCache->OnClick.Add([=](EventParams &e) {
 			settingInfo_->Show(gr->T("VertexCache Tip", "Faster, but may cause temporary flicker"), e.v);