diff --git a/UI/ImDebugger/ImDebugger.cpp b/UI/ImDebugger/ImDebugger.cpp
index 435915ff62..861395d6f7 100644
--- a/UI/ImDebugger/ImDebugger.cpp
+++ b/UI/ImDebugger/ImDebugger.cpp
@@ -2656,6 +2656,10 @@ ImDebugger::ImDebugger() {
 }
 
 ImDebugger::~ImDebugger() {
+	SaveConfig();
+}
+
+void ImDebugger::SaveConfig() {
 	cfg_.SaveConfig(ConfigPath());
 }
 
diff --git a/UI/ImDebugger/ImDebugger.h b/UI/ImDebugger/ImDebugger.h
index b79209b509..caf982a6b9 100644
--- a/UI/ImDebugger/ImDebugger.h
+++ b/UI/ImDebugger/ImDebugger.h
@@ -190,6 +190,7 @@ public:
 		externalCommand_ = cmd;
 	}
 	void DeviceLost();
+	void SaveConfig();
 
 private:
 	Path ConfigPath();
diff --git a/UI/NativeApp.cpp b/UI/NativeApp.cpp
index bbbf6cf386..6c3f2a73cb 100644
--- a/UI/NativeApp.cpp
+++ b/UI/NativeApp.cpp
@@ -436,6 +436,7 @@ void runImDebugger(Draw::DrawContext *draw) {
 
 		// Convert to drawlists.
 		ImGui::Render();
+		ImGui_ImplPlatform_SaveIni(false);
 		wantTextInput = io.WantTextInput;
 	} else {
 		uiContext->SetOverrideScreenFrame(nullptr);
@@ -1128,19 +1129,13 @@ void NativeShutdownGraphics(GraphicsContext *graphicsContext) {
 		gpu->DeviceLost();
 	}
 
+	// The imgui context and the debugger outlive the graphics, so that their state survives Android
+	// switching away from the app. Save now anyway, since the app may be killed in the background.
 	if (imguiInited_) {
-		if (imDebugger_) {
-			imDebugger_->DeviceLost();
-		}
+		imDebugger_->DeviceLost();
+		imDebugger_->SaveConfig();
+		ImGui_ImplPlatform_SaveIni(true);
 		ImGui_ImplThin3d_DestroyDeviceObjects();
-		ImGui_ImplThin3d_Shutdown();
-		// Destroy the debugger here, while the things it refers to are still alive. If left to
-		// static destruction, ~ImDisasmView runs after Core's globals are gone and its
-		// g_disassemblyManager.clear() walks a destroyed map (and locks a destroyed mutex).
-		imDebugger_.reset();
-		ImGui::DestroyContext(ctx_);
-		ctx_ = nullptr;
-		imguiInited_ = false;
 	}
 
 #if PPSSPP_PLATFORM(WINDOWS) && !PPSSPP_PLATFORM(UWP)
@@ -1979,6 +1974,19 @@ void NativeShutdown() {
 		g_screenManager = nullptr;
 	}
 
+	if (imguiInited_) {
+		ImGui_ImplPlatform_SaveIni(true);
+		// The device objects went with NativeShutdownGraphics.
+		ImGui_ImplThin3d_Shutdown();
+		// Destroy the debugger here, while the things it refers to are still alive. If left to
+		// static destruction, ~ImDisasmView runs after Core's globals are gone and its
+		// g_disassemblyManager.clear() walks a destroyed map (and locks a destroyed mutex).
+		imDebugger_.reset();
+		ImGui::DestroyContext(ctx_);
+		ctx_ = nullptr;
+		imguiInited_ = false;
+	}
+
 	System_Notify(SystemNotification::BEFORE_CONFIG_SAVE_ON_EXIT);
 
 	g_Config.Save("NativeShutdown");
diff --git a/ext/imgui/imgui_impl_platform.cpp b/ext/imgui/imgui_impl_platform.cpp
index eda6490851..dfaff32157 100644
--- a/ext/imgui/imgui_impl_platform.cpp
+++ b/ext/imgui/imgui_impl_platform.cpp
@@ -1,5 +1,6 @@
 #include "ext/imgui/imgui.h"
 #include "Common/File/Path.h"
+#include "Common/File/FileUtil.h"
 #include "Common/Input/KeyCodes.h"
 #include "Common/Data/Encoding/Utf8.h"
 #include "Common/System/Display.h"
@@ -10,6 +11,7 @@
 #include "imgui_impl_platform.h"
 
 static ImGuiMouseCursor g_cursor = ImGuiMouseCursor_Arrow;
+static Path g_iniPath;
 
 void ImGui_ImplPlatform_KeyEvent(const KeyInput &key) {
 	ImGuiIO &io = ImGui::GetIO();
@@ -86,10 +88,28 @@ void ImGui_ImplPlatform_TouchEvent(const TouchInput &touch) {
 }
 
 void ImGui_ImplPlatform_Init(const Path &configPath) {
-	static char path[1024];
-	truncate_cpy(path, configPath.ToString());
-	ImGui::GetIO().IniFilename = path;
+	// imgui's own ini handling uses fopen, which can't reach a memstick behind an Android content URI.
+	g_iniPath = configPath;
+	ImGui::GetIO().IniFilename = nullptr;
 	ImGui::GetIO().ConfigFlags |= ImGuiConfigFlags_DockingEnable;
+
+	std::string data;
+	if (File::ReadTextFileToString(g_iniPath, &data)) {
+		ImGui::LoadIniSettingsFromMemory(data.data(), data.size());
+	}
+}
+
+void ImGui_ImplPlatform_SaveIni(bool force) {
+	ImGuiIO &io = ImGui::GetIO();
+	if (!force && !io.WantSaveIniSettings) {
+		return;
+	}
+	size_t size = 0;
+	const char *data = ImGui::SaveIniSettingsToMemory(&size);
+	if (!File::WriteDataToFile(true, data, size, g_iniPath)) {
+		WARN_LOG(Log::System, "Failed to save imgui settings to '%s'", g_iniPath.c_str());
+	}
+	io.WantSaveIniSettings = false;
 }
 
 void ImGui_ImplPlatform_AxisEvent(const AxisInput &axis) {
diff --git a/ext/imgui/imgui_impl_platform.h b/ext/imgui/imgui_impl_platform.h
index c6bec60101..4e6f0f8c3f 100644
--- a/ext/imgui/imgui_impl_platform.h
+++ b/ext/imgui/imgui_impl_platform.h
@@ -11,6 +11,8 @@ ImGuiKey KeyCodeToImGui(InputKeyCode keyCode);
 
 void ImGui_ImplPlatform_Init(const Path &configPath);
 void ImGui_ImplPlatform_NewFrame();
+// Writes the ini if imgui asked for it, or always if force is set. Call after ImGui::Render.
+void ImGui_ImplPlatform_SaveIni(bool force);
 
 void ImGui_ImplPlatform_KeyEvent(const KeyInput &key);
 void ImGui_ImplPlatform_TouchEvent(const TouchInput &touch);