diff --git a/cmake/BuildParameters.cmake b/cmake/BuildParameters.cmake
index 82d52401d8..b70158ef54 100644
--- a/cmake/BuildParameters.cmake
+++ b/cmake/BuildParameters.cmake
@@ -238,7 +238,10 @@ elseif(CMAKE_BUILD_TYPE MATCHES "Release")
 endif()
 
 if (USE_ASAN)
-    set(ASAN_FLAG "-fsanitize=address -fno-omit-frame-pointer -g -mpreferred-stack-boundary=4 -mincoming-stack-boundary=2 -DASAN_WORKAROUND")
+    set(ASAN_FLAG "-fsanitize=address -fno-omit-frame-pointer -g -DASAN_WORKAROUND")
+    if(${PCSX2_TARGET_ARCHITECTURES} MATCHES "i386")
+        set(ASAN_FLAG "${ASAN_FLAG} -mpreferred-stack-boundary=4 -mincoming-stack-boundary=2")
+    endif()
 else()
     set(ASAN_FLAG "")
 endif()