diff --git a/pcsx2-qt/EmuThread.cpp b/pcsx2-qt/EmuThread.cpp
index f4cf66c45f..11626b42cf 100644
--- a/pcsx2-qt/EmuThread.cpp
+++ b/pcsx2-qt/EmuThread.cpp
@@ -113,7 +113,7 @@ void EmuThread::startVM(std::shared_ptr<VMBootParameters> boot_params)
 
 	// create the display, this may take a while...
 	m_is_fullscreen = boot_params->fullscreen.value_or(QtHost::GetBaseBoolSettingValue("UI", "StartFullscreen", false));
-	m_is_rendering_to_main = !m_is_fullscreen && QtHost::GetBaseBoolSettingValue("UI", "RenderToMainWindow", true);
+	m_is_rendering_to_main = QtHost::GetBaseBoolSettingValue("UI", "RenderToMainWindow", true);
 	if (!VMManager::Initialize(*boot_params))
 		return;
 
diff --git a/pcsx2-qt/MainWindow.cpp b/pcsx2-qt/MainWindow.cpp
index 16ce37efe5..50ee089792 100644
--- a/pcsx2-qt/MainWindow.cpp
+++ b/pcsx2-qt/MainWindow.cpp
@@ -1108,8 +1108,6 @@ void MainWindow::closeEvent(QCloseEvent* event)
 
 DisplayWidget* MainWindow::createDisplay(bool fullscreen, bool render_to_main)
 {
-	pxAssertRel(!fullscreen || !render_to_main, "Not rendering to main and fullscreen");
-
 	HostDisplay* host_display = Host::GetHostDisplay();
 	if (!host_display)
 		return nullptr;